Viral miRNA targeting of bicistronic and polycistronic transcripts
نویسندگان
چکیده
منابع مشابه
New insights into polycistronic transcripts in eukaryotes.
In bacteria and archaea, many functionally related genes are organized into operons in order to be transcribed and translated simultaneously. Operons are rarely seen in eukaryotes except for the Trypanosome and nematode, in which they are first transcribed into polycistronic transcripts but then processed into individual mature mRNAs. Recently, several researchers described the findings of poly...
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Genomic segment S12 of rice dwarf virus and segment S9 of wound tumor virus, both members of the genus Phytoreovirus, have small out-of-phase overlapping open reading frames (ORFs). Western blot (immunoblot) analysis revealed that rice dwarf virus S12 mRNA specified translation products from the large ORF and two overlapping small ORFs both in rice plant hosts and in Spodoptera frugiperda insec...
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Alternative polyadenylation sites produce transcript isoforms with 3' untranslated regions (UTRs) of different lengths. If a microRNA (miRNA) target is present in the UTR, then only those target-containing isoforms should be sensitive to control by a cognate miRNA. We carried out a systematic examination of 3' UTRs containing multiple poly(A) sites and putative miRNA targets. Based on expressed...
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Thyroid cancer is one of the most common malignancies of endocrine glands, causing carcinomas, such as papillary, follicular, medullary, and anaplastic thyroid carcinomas. Due to the significance of thyroid carcinomas, identification of the main signaling pathways and the affecting mutations has been considered by researchers. Further studies on the dysregulation of oncogenes in signaling path...
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ژورنال
عنوان ژورنال: Current Opinion in Virology
سال: 2014
ISSN: 1879-6257
DOI: 10.1016/j.coviro.2014.04.004